Back ديفينهيدرامين Arabic دیفن هیدرامین AZB Дифенхидрамин Bulgarian Difenhidramina Catalan Deuffenhydramin Welsh Diphenhydramin German Διφαινυδραμίνη Greek Dufenhidramino Esperanto Difenhidramina Spanish Difenhidramina Basque
Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative. It is a first-generation H1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects.[11][2] Diphenhydramine is also a potent anticholinergic.[12] It is mainly used to treat allergies, insomnia, and symptoms of the common cold. It is also less commonly used for tremors in parkinsonism, and nausea.[11] It is taken by mouth, injected into a vein, injected into a muscle, or applied to the skin.[11] Maximal effect is typically around two hours after a dose, and effects can last for up to seven hours.[11]
Common side effects include sleepiness, poor coordination, and upset stomach.[11] There is no clear risk of harm when used during pregnancy; however, use during breastfeeding is not recommended.[13]
It was developed by George Rieveschl and put into commercial use in 1946.[14][15] It is available as a generic medication,[11][11] In 2022, it was the 258th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[16][17]
Its sedative and deliriant effects have led to some cases of recreational use.[18][2]
- ^ Hubbard JR, Martin PR (2001). Substance Abuse in the Mentally and Physically Disabled. CRC Press. p. 26. ISBN 978-0-8247-4497-7.
- ^ a b c Saran JS, Barbano RL, Schult R, Wiegand TJ, Selioutski O (October 2017). "Chronic diphenhydramine abuse and withdrawal: A diagnostic challenge". Neurology. Clinical Practice. 7 (5): 439–441. doi:10.1212/CPJ.0000000000000304. PMC 5874453. PMID 29620065.
- ^ "Benylin Chesty Coughs (Original) - Summary of Product Characteristics (SmPC)". (emc). 24 February 2022. Archived from the original on 30 December 2022. Retrieved 29 December 2022.
- ^ "Diphenhydramine- diphenhydramine hydrochloride injection, solution". DailyMed. 11 November 2019. Retrieved 18 May 2024.
- ^ a b Cite error: The named reference
pmid2866055was invoked but never defined (see the help page). - ^ Cite error: The named reference
AHFSwas invoked but never defined (see the help page). - ^ Cite error: The named reference
pmid2391399was invoked but never defined (see the help page). - ^ a b Garnett WR (February 1986). "Diphenhydramine". American Pharmacy. NS26 (2): 35–40. doi:10.1016/s0095-9561(16)38634-0. PMID 3962845.
- ^ Cite error: The named reference
pmid19153052was invoked but never defined (see the help page). - ^ "Showing Diphenhydramine (DB01075)". DrugBank. Archived from the original on 31 August 2009. Retrieved 5 September 2009.
- ^ a b c d e f g "Diphenhydramine Hydrochloride". Drugs.com. American Society of Health-System Pharmacists. 6 September 2016. Archived from the original on 15 September 2016. Retrieved 28 September 2016.
- ^ Ayd FJ (2000). Lexicon of Psychiatry, Neurology, and the Neurosciences. Lippincott Williams & Wilkins. p. 332. ISBN 978-0-7817-2468-5. Archived from the original on 8 September 2017.
- ^ "Diphenhydramine Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 2 October 2016. Retrieved 28 September 2016.
- ^ Dörwald FZ (2013). Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds. John Wiley & Sons. p. 225. ISBN 978-3-527-64565-7. Archived from the original on 2 October 2016.
- ^ "Benadryl". Ohio History Central. Archived from the original on 17 October 2016. Retrieved 28 September 2016.
- ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
- ^ "Diphenhydramine Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
- ^ Cite error: The named reference
Thomas2008was invoked but never defined (see the help page).